18F-FDG PET/CT在寻找不明原发灶肿瘤患者原发灶中的价值

目的 探讨18F-FDG PET/CT在诊断不明原发灶肿瘤(CUP)患者原发灶中的价值.资料与方法 36例CUP患者行PET/CT检查拟寻找原发灶,根据转移灶部位分为淋巴结转移组(8例)、肝转移组(9例)、骨转移组(12例)及恶性胸腹水组(7例),比较18F-FDG PET/CT诊断淋巴结转移组与非淋巴结转移组CUP患者原发灶的灵敏度.结果 18F-FDG PET/CT寻找CUP原发灶的灵敏度为63.9％ (23/36),PET/CT诊断淋巴结转移组、肝转移组、骨转移组及恶性胸腹水组患者原发灶的灵敏度分别为87.5％ (7/8)、55.6％ (5/9)、58.3％(7/12)、57.1％ (4/7).18F-FDG PET/CT对淋巴结转移组原发灶的确诊率87.5％(7/8)]显著高于非淋巴结转移组57.1％( 16/28)],差异有统计学意义(P＜0.05).结论 18F-FDG PET/CT诊断CUP患者原发灶灵敏度较高,尤其适用于发生淋巴结转移的CUP患者.

Value of Detecting Primary Focus in Carcinoma of Unknown Primary Using 18F-FDG PET/CT

Purpose To explore the value of 18 F-FDG PET/CT in the diagnosis of primary focus for patients with carcinoma of unknown primary (CUP).Materials and Methods Thirty-six patients with CUP underwent PET/CT to detect the primary focus,and further divided into lymph node metastasis group (n=8),liver metastasis group (n =9),bone metastasis group (n=12),malignant hydrothorax and ascites group (n=7) according to sites of metastasis.The sensitivity of diagnosing primary focus in patients with CUP between lymph node metastasis group and nonlymph node metastasis group using PET/CT was analyzed.Results The sensitivity of 18 F-FDG PET/CT in detecting primary focus for patients with CUP was 63.9% (23/36),the sensitivities in lymph node metastasis group,liver metastasis group,bone metastasis group,malignant hydrothorax and ascites group were 87.5% (7/8),55.6% (5/9),58.3% (7/12),57.1% (4/7),respectively.The diagnostic rate in lymph node metastasis group 87.5% (7/8)] was statistically higher than that of non-lymph node metastasis group 57.1% (16/28)] (P<0.05).Conclusion 18 F-FDG PET/CT is sensitive to diagnose the primary focus for patients with CUP,especially for patients with lymph node metastasis.