妇炎舒胶囊对大鼠慢性盆腔炎治疗作用的研究

目的:观察妇炎舒胶囊对混合菌液致慢性盆腔炎大鼠模型的影响,探讨其治疗慢性盆腔炎的作用机制。方法:60只SD大鼠随机分为6组:假手术组(蒸馏水10ml/kg)、模型组、金鸡胶囊组(0.65g/kg)、妇炎舒胶囊大剂量组(1.8g/kg)、妇炎舒胶囊中剂量组(0.9g/kg)和妇炎舒胶囊小剂量组(0.45g/kg)。采用子宫内注射混合菌液造成大鼠慢性盆腔炎模型,连续给药28天后,观察妇炎舒对大鼠子宫内膜的组织形态学改变,检测血液流变学指标的变化。结果:0.9g/kg和1.8g/kg妇炎舒对混合菌液致子宫内膜炎大鼠体重下降具有一定的减轻作用,可降低大鼠子宫卵巢脏体比值,明显改善子宫内膜上皮细胞增生、变性、坏死改变以及炎细胞浸润和子宫内膜充血、水肿等改变;0.45g/kg、0.9g/kg和1.8g/kg妇炎舒与模型组比较,降低全血粘度、全血还原粘度、红细胞聚集指数、压积。结论:妇炎舒胶囊对混合菌液致大鼠慢性盆腔炎有治疗作用,其作用机制与改善血液流变学有关。

Therapeutic effects of Fuyanshu Capsule on chronic pelvic inflammation of rats

Objective: To observe the effects of Fuyanshu Capsule on chronic pelvic inflammation of rats induced by a mixture of bacterium suspension and the possible mechanism of the therapeutic effects.Methods: Chronic pelvic inflammation of rats was caused by injection of a mixture of bacteriums suspension into injured womb.Sixty rats were random divided into 6 groups,including sham-operation group(distilled water,10ml/kg),model group,Jinji capsule group(0.65g/kg) and Fuyanshu capsule groups(1.8g/kg,0.9g/kg,0.45g/kg).After the rats were treated 28 days with corresponding medicine intragastric administration,the pathological of endometrium and the parameters of hemorrheology were used to evaluate the effects of Fuyanshu capsule.Results: Fuyanshu capsule(0.9g/kg and 1.8g/kg) reduced the ratio value of the swelling womb and ovaries to body weight of the rats.Fuyanshu capsule ameliorated obviously the endometrium epithelial hyperplasia,degeneration,inflammation cell infiltration,and endometrium congestion and swell.Fuyanshu capsule(0.45g/kg,0.9g/kg and 1.8g/kg) decreased whole blood viscosity,whole blood reduced viscosity,erythrocyte aggregation index and volume of packed red cells.Conclusions: The therapeutic effects of Fuyanshu Capsule on chronic pelvic inflammation induced by a mixture of bacterium suspension in rats is related to the improvement of hemorrheology variation.