18F-FDG PET/CT诊断非小细胞肺癌中最大标准摄值法适宜诊断界值的研究

目的 探讨18F-FDG PET/CT最大标准摄取值(SUVmax)在非小细胞肺癌(NSCLC)中的适宜诊断界值.资料与方法 102例行胸部或全身PET/CT检查并经支气管内镜病理、肿块穿刺细胞学检查、术后病理确诊证实的肺部良、恶性病变患者,根据Youden指数最大原则、误诊率与漏诊率同等重要原则、正确率最大原则寻找18F-FDG PET/CT SUVmax鉴别NSCLC与肺良性病变的适宜诊断标准.结果 18F-FDG PET/CT诊断NSCLC与肺良性病变时,Youden指数最大原则下的适宜诊断界值为S UVmax=2.8,误诊率与漏诊率同等重要原则下的适宜诊断界值为SUVmax=5.45,正确率最大原则下的适宜诊断界值为SUVmax=2.8.结论 SUVmax鉴别NSCLC与肺良性病变的适宜诊断标准为2.8.

Optimized Cutoff Value of Maximum Standardized Uptake Value for Diagnosing Non-small Cell Lung Cancer Using(18)~F-FDG PET/CT

Purpose To investigate the suitable cutoff value of maximum standardized uptake value(SUVmax) for diagnosing non-small cell lung cancer(NSCLC) using 18 F-FDG PET/CT.Materials and Methods 102 patients with malignant or benign pulmonary lesions proved by pathology underwent PET/CT.The suitable cutoff value of SUVmax for 18 F-FDG PET/CT was determined to differentiate NSCLC from pulmonary benign lesions based on Youden’s index maximum,rate of equal false positive and false negative and accuracy maximum principle.Results The optimal cutoff values of SUVmax were 2.8,5.45 and 2.8,respectively according to the rule of Youden’s index maximum,rate of equal false positive and false negative,and the accuracy maximum.Conclusion The optimal cutoff value of SUVmax to differentiate NSCLC from pulmonary benign lesions is 2.8.