维医药综合治疗与白癜风患者神经内分泌免疫功能的相关性研究

目的:探讨维医药综合治疗白癜风及其对患者神经内分泌免疫功能的相关性。方法:白癜风患者采用维医药综合治疗方法,进行治疗前、中、后疗效及安全性评价,采用酶联免疫吸附试验测定治疗前或用药前、用药后患者血清5-HT等15项神经内分泌免疫因子水平,并与正常人对照组比较;同时心理干预前后测定血清CRH、ACTH、CORTIS水平并与正常对照组比较。结果:维医对白癜风临床痊愈率11.4%、显效率49.3%、有效率33.1%、无效率6.2%,总有效率为93.8%,其中成熟剂和清除剂对控制白斑的扩散有显著的作用(P<0.01)。入组患者治疗前ANG-II、EP-β、IFN-γ、sICAM-1、5-HT、IL-10、IgG抗体、NE、Cortisol、E的浓度显著高于对照组(P<0.01),而TNF-α、IL-8、IL-2、IL-6浓度低于对照组(P<0.01);治疗后5-HT、IL-10、sICAM-1、EP-β、E等指标较治疗前降低(P<0.05),IFN-γ、NE、ACTH、IgG抗体等指标较治疗前升高(P<0.05);心理干预后,干预组HAMA、HRSD评分低于对照组。结论:白癜风发生和发展过程是一个神经内分泌免疫网络的综合效应过程,这与维医自然力失调致白癜风理论相映,是一种失衡的状态,而疾病的发展是这种状态的升级,其产生与存在反馈抑制代谢补偿等动态效应过程;维医药对白癜风具有独特的疗效,心理干预提高维医药对白癜风的治愈率。

Study on the correlation of uyghur medical treatment and neuroendocrine immune function of vitiligo

Object: To explore the correlation of Uyghur Medical treatment and neuroendocrine immune function of vitiligo.Method: Vitiligo patients were treated with Comprehensive Treatment of Uyghur Medicine.The efficacy and safety evaluation were checked beforehand,during and after the treatment as well as the serum 5-HT and the level of 15 other neuroendocrine immune factors and compared with normal control group.At the same time,serum CRH,ACTH,CORTIS level is measured before and after psychological intervention and compared with normal control group.Result: Uyghur medicine for vitiligo clinical cure rate 11.4%,markedly effective rate was 49.3%,33.1% efficiency,the inefficiency of 6.2%,the total effective rate was 93.8%,Munziq and Mussil have a significant effect on controlling the proliferation of leukoplakia,(P <0.01).Before treatment,ANG-II,EP-beta,IFN-gamma,sICAM-1,5-HT,IL-10 IgG antibody,NE,Cortisol,E concentration of vitiligo patient group was significantly higher than the control group(P <0.01),therefore TNF-alpha,IL-8,IL-2,IL-6 concentrations was lower than the control group(P <0.01).After treatment,5-HT and IL-10,sICAM-1,EP-beta,E and other indicators decreased than before treatment(P <0.05),therefore IFN-gamma,NE,ACTH and IgG antibody index increased than before treatment(P <0.05).After psychological intervention,the intervention group HAMA,HRSD score lower than the control group.Conclusion: The development process of vitiligo is the combined effect of a neuroendocrine-immune network,which is matched with the Uyghur Medicine theory that vitiligo is caused by the disorders of natural forces,a state of imbalance,therefore the development of the disease is the upgrade of this state,emergence and existence of this state can feedback inhibit the dynamic effects of metabolic compensation.Uyghur Medicine has a unique effect on vitiligo,and psychological intervention help improve the cure rate of Uyghur Medicine for vitiligo.