| 间期荧光原位杂交技术(FISH)在急性淋巴细胞性白血病(ALL)8号染色体三体检测中的应用 |
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| 引用本文： | 潘金兰,李建勇,薛永权,申咏梅,过宇,吴亚芳. 间期荧光原位杂交技术(FISH)在急性淋巴细胞性白血病(ALL)8号染色体三体检测中的应用[J]. 肿瘤, 2002, 22(5): 366-367 |
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| 作者姓名： | 潘金兰 李建勇 薛永权 申咏梅 过宇 吴亚芳 |
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| 作者单位： | 苏州大学附属第一医院,江苏省血液研究所,苏州215006 |
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| 摘 要： | 目的 探讨间期荧光原位杂交 (FISH)技术对于ALL三体 8检测的价值。方法 采用荧光素SpectrumRed直接标记 8号染色体着丝粒探针 ,检测了 5 9例ALL病例和 8例正常对照组骨髓细胞 ,并与细胞遗传学 (CG)结果相比较。结果 5 9例ALL病例中 ,8例FISH检测为三体 8阳性 ;CC检测仅 3例为阳性。结论 间期FISH对ALL三体 8检测有重要意义 ,是CG的重要补充。
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| 关 键 词： | 荧光原位杂交 急性淋巴细胞性白血病 8号染色体 |
| 修稿时间： | 2001-04-29 |
Application of interphase fluorescence in situ hybridization to detect the trisomy 8 in acute lymphocytic leukemia |
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| PAN Jinlan,LI Jianyong,XUE yongquan,et al.. Application of interphase fluorescence in situ hybridization to detect the trisomy 8 in acute lymphocytic leukemia[J]. Tumor, 2002, 22(5): 366-367 |
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| Authors: | PAN Jinlan LI Jianyong XUE yongquan et al. |
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| Abstract: | Objective To explore the value of interphase fluorescence in situ hybridization to the detection of trisomy 8 in acute lymphocytic leukemia. Methods Interphase FISH using Spectrum Red labeled chromosome 8 centromere specific probe was carried out to detect trisomy 8 in 59 cases of ALL and 8 normal controls. Results Trisomy 8 was detected by FISH in 8 of 59 cases of ALL, however,it was detected by CG only in 3 of them. Conclusion Interphase FISH was an useful method for the detection of trisomy 8 in ALL. It was an important complement to CG. |
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| Keywords: | FISH Acute lymphocytic leukemia chromosome 8 |
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