山医群体中国地鼠自发的遗传性糖尿病模型

经过五年的工作,我们在一般实验室条件下,对野生地鼠进行驯养和近亲交配,繁育成目前国内较大的中国地鼠山医群体,并建成自发的遗传性糖尿病模型。模型的特点是:动物为非肥胖型,血糖呈中、轻度增高,血清胰岛素浓度表现多样,胰岛病变程度不一,糖尿病发病率受饮食因素影响,且具有多基因遗传特点。相似于人类非胰岛素依赖型糖尿病(NIDDM)。

Spontaneous hereditary diabetes mellitus in the Shanyi colony of Chinese hamster (Cricetulus barabensis griseus)

After five years of study,under general laboratory condition,the authors have domesticated the wild hamster and through inbreeding succeeded in breeding Shan-yi colony of Chinese hamster,the largest population in China at present;They have also established the spontaneous hereditary diabetes mellitus model.The characteristics of this model are leanness,light or moderate increase in fasting blood glucose levels,normal,higher or lower serum insulin of diabetic hamster and the variable of the pathological changes of islets.Incidence of diabetes mellitus is influenced by diet factor,and characterized by polygenic inheritance.This model is similar to human non-insulin dependent diabetes mellitus(NIDDM).