HIV/AIDS合并药疹患者实验室资料和预后的相关性研究

目的 了解HIV/AIDS患者发生药疹对内脏系统的影响及导致患者死亡的相关因素.方法 对72例HIV/AIDS合并药疹住院患者进行人口学资料、流行病学资料、实验室检查及疾病转归情况研究.结果 HIV/AIDS合并药疹患者病死率为6.9％,均死于感染,CD4＋T淋巴细胞数＜200 cells/μl者病死率为10.6％,病毒载量高于1×102 copies/ml者病死率为10.2％.55.3％患者天冬氨酸氨基转移酶升高,54.1％患者丙氨酸氨基转移酶升高,22.2％患者总胆红素升高,4.2％肾功能损伤,9.1％患者白蛋白减低,白蛋白降低患者病死率为16.1％,50.0％白细胞总数减少,45.9％中性粒细胞减少,33.3％淋巴细胞减低,低淋巴细胞病死率为12.5％,红细胞减少患者病死率10.3％,低血红蛋白病死率为16.4％.结论 感染是HIV/AIDS合并药疹患者的主要死亡原因,低CD4＋T淋巴细胞、高病毒载量、低蛋白血症、低淋巴细胞、低红细胞及低血红蛋白提示患者预后不良.

Correlation study of laboratory data and prognosis among HIV/AIDS patients with drug eruptions

Objective To investigate the impact on the internal organs generated by the drug eruptions among HIV/ AIDS patients and the factors leading to the death. Methods Evaluating demographic data, epidemiological data, labo- ratory examination and prognosis of 72 cases of HIV/AIDS inpatients with drug eruption were collected and analgzed. Results The mortality of HIV/AIDS patients with drug eruption was 6. 9%, which died of infection. The mortality of patients with CD4＋ T lymphocyte count〈200 cells/p3 and the viral load higher than lxl02 copies/ml were 10. 6% and 10. 2% respectively. Cases with high aspartate transaminase,high alanine aminotransferase,high total bilirubin, kidney damage and low albumin were 55.3% ,54. 1% ,22. 2% ,4. 2% and9. 1% respectively. The mortality of patients with low albumin was 16. 1%. Fifty percent of the patients suffering from the decresed total number of white blood cells, 45.9% with decreased neutropenia, and 33.3% with decreased lymphocytes. The mortality of patients with low lymphocyte, low red blood cells and low hemoglobin were 12. 5%, 10. 3% and 16. 4% respectively. Conclusion Infection was the main cause of death among HIV/AIDS patients with drug eruption. Patients with low CD4＋ T lymphocyte count, high viral load, hypoalbuminemia, low lymphocyte, low red blood cell and hemoglobin suggest poor prognosis.