Bias of the estimated recombination fraction and lod score due to an association between a disease gene a marker gene |
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| Authors: | F. CLERGET-DARPOUX |
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| Affiliation: | Group de Recherches de Génétique Épidémiologique, Château de Longchamp, Bois de Boulogne, Paris 16éme, France |
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| Abstract: | An association between a recessive disease gene and a biallelic codominant linked marker is shown to induce some bias in the estimation of the recombination fraction by the lod score method. We demonstrate that ignoring the association may lead to an underestimate of the true recombination fraction and the lod score. |
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