Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development |
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Authors: | G Garthwaite B Yamini J Garthwaite |
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Institution: | Department of Veterinary Physiology and Pharmacology, University of Liverpool, U.K. |
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Abstract: | Depolarizing responses of Purkinje and granule cells to excitatory amino acid receptor agonists were recorded from rat cerebellar slices at various stages of postnatal maturation using a gap technique. No major developmental changes in relative potency or efficacy of kainate and quisqualate were observed. However, Purkinje and granule neurones both became less responsive to N-methyl-D-aspartate (NMDA) with age, most dramatically so between 14 and 21 days. This transient chemosensitivity to NMDA may reflect a special role of the NMDA receptor system in cerebellar development. |
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