米非司酮治疗围绝经期功能失调性子宫出血57例临床分析

目的:探讨米非司酮治疗围绝经期功能失调性子宫出血临床效果。方法:选择2003年9月~2006年1月在东莞市人民医院确诊为围绝经期功血的患者57例,每晚睡前空腹口服米非司酮12.5 mg,每天一次,连续6个月,于治疗前及治疗3个月、6个月分别检测性激素6项、肝肾功能及血常规,观察月经情况,B超监测子宫内膜厚度。结果:治疗期间所有患者均闭经,血促卵泡生成素(FSH)、促黄体生成素(LH)、泌乳素(PRL)、睾酮(T)变化不明显,血孕酮(P)和雌二醇(E2)水平明显(P<0.01);子宫内膜变薄,由用药前(1.0±0.3)cm至用药后(0.4±0.2)cm(P<0.05);血红蛋白均有不同程度的提高,贫血得到改善。结论:米非司酮治疗围绝经期功能失调性子宫出血是一种安全有效的治疗方法,值得临床推广。

Cinic Effect of Mifepristone on Dysfunctional Uterine Bleeding in Perimenopausal

Objective To study the clinic effect of mifepristone on dysfunctional uterine bleeding in perimenopausal.Methods This study chooses 57 patients who were diagnosed as dysfunctional uterine bleeding in perimenopausal in the People's Hospital of Dong Guan city,these patients were treated with mifepristone 12.5 mg,orally taken on empty stomach,once a day before sleep every evening for 6 successive months,and detect 6 sex hormone blood routine examination,the liver and kidney functions,observe menstrual and at the same time measure the thickness of endometrium by B-ultrasonic before and 3 months and 6 months after treatment respectively.Results All the patients were amenorrhea during the period of taking medicine,FSH,LH,PRL and T serum levels of the three groups unchanged significantly,and the difference of E2 and P serum levels' decreasing is statistically significant(P<0.01);Endometrium were thinner and atrophy from(1.0±0.3) cm to(0.4±0.2) cm(P<0.05);Hemoglobin and anaemia had been improved in varying degree.Conclusion Treatment of dysfunctional uterine bleeding in perimenopausal with Mifepristone is a safe and validity method,which is deserved the clinical expansion.