Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production |
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| Authors: | Flores-Mendoza Lilian Silva-Campa Erika Reséndiz Mónica Osorio Fernando A Hernández Jesús |
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| Affiliation: | Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a la Victoria, Km. 0.6., Hermosillo, Sonora, México. |
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| Abstract: | Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation. |
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