新生霉素对人肝癌细胞的抑制作用

 目的　研究新生霉素 (NOVO)对人肝癌细胞的抗癌及其对临床常用抗癌药的调节作用。方法　采用抗癌药敏感试验 (MTT法 ) ,测定NOVO和 5种临床常用抗癌药单独应用对手术切除的原发性肝癌病人的肝癌细胞的抑制作用 ,同时测定NOVO和此 5种抗癌药联合应用的抑制作用。结果　NOVO对人肝癌细胞有抗癌作用 ,与 5种抗癌药联合应用对肝癌细胞的抑制率在低、中、高浓度均高于 5种抗癌药单独应用 ,差异均有显著性 ,P <0 .0 5。结论　结果表明NOVO对人肝癌细胞有较强的抗癌作用 ,并对诸如MMC、5 FU、DDP、CTX、ADM等有加强作用 ;NOVO可能有较大的临床应用价值

Antitumor effect of novobiocin on patients''''primary liver cancer cells

Objective To study the antitumor effect of novobiocin(NOVO) on patients'primary liver cancer cells, and the modulation of NOVO on some clinical antitumor drugs.Methods Using antitumor agent sensitive assay(MTT method),the inhibiting effects of NOVO and five antitumor agents(MMC, 5|FU, DDP,CTX, ADM)on patients'primary liver cancer cells were assayed, and the inhibiting effects of NOVO combining with one of the antitumor agents were also assayed respectively. Results NOVO had antitumor effect on patients'primary liver cancer cells . At three concentrations, the antitumor effects of NOVO combining with one of the antitumor agents were higher than those of the five antitumor agents used alone( P <0.05). Conclusion The results of our study indicated that NOVO had antitumor effect on patients'primary liver cancer cells, and it can enhanced antitumor effects of some clinical antitumor agents such as MMC, 5|FU, DDP, CTX and ADM. It suggests that NOVO has obvious clinical value, it might play a role in tumor chemotherapy.