| 口服硫酸氢黄连素脂质体的研制 |
| |
| 引用本文： | 薛玉英,翁帼英,何俊峰,徐斌. 口服硫酸氢黄连素脂质体的研制[J]. 中国中药杂志, 1995, 20(12): 730-731 |
| |
| 作者姓名： | 薛玉英 翁帼英 何俊峰 徐斌 |
| |
| 作者单位： | 南京药物研究所 210009,**深圳卫武光明生物制品厂 518107 |
| |
| 摘 要： | 以硫酸氢黄连素与PVP之比为1:5制成共沉淀物,采用药脂比为1:20、胆固醇与豆磷脂之比为2:7制备硫酸氢黄连素脂质体,包封率为48.72%。经大鼠在体小肠吸收试验表明:脂质体与游离药物相比,增加吸收值4倍多。
|
| 关 键 词： | 硫酸氢黄连素 脂质体 小肠吸收 |
| 收稿时间： | 1994-12-12 |
The Preparation of Oral Berberine Bisulfate Liposomes |
| |
| Xue Yuying; Weng Guoying; He Junfeng; Xu Bin. The Preparation of Oral Berberine Bisulfate Liposomes[J]. China Journal of Chinese Materia Medica, 1995, 20(12): 730-731 |
| |
| Authors: | Xue Yuying Weng Guoying He Junfeng Xu Bin |
| |
| Affiliation: | Nanjing Institute of Materia Medica 210009 |
| |
| Abstract: | The co-precipitate has been made from berberine bisulfate and polyvingl pyrrolidone (PVP) with theratio of 1 : 5. The liposomes entrapped berberine bisulfate have been prepared with the ration of drug to lipid 1 : 20and the ratio of cholesterol to soy phosphatide 2 : 7. The percentage of encapsulation is 48. 72%. The test in vivo ofsmall intestinal absorption in rats shows that liposomes can increase the abserption by 4-fold odd compared with freeber-berine bisulfate. |
| |
| Keywords: | berberine bisulfate liposomes small intestinal absorption |
| 本文献已被 CNKI 维普 等数据库收录！ |
