奥曲肽在急性胰腺炎抗炎及免疫调节中的作用

目的：观察奥曲肽在急性胰腺炎治疗过程中的抗炎及免疫调节作用。方法：60例确诊为急性胰腺炎的患者，随机分为实验组（30例）和对照组（30例）。对照组给予常规治疗，实验组在常规治疗的基础上给予静脉滴注奥曲肽治疗。结果：与对照组相比，实验组静脉血中的内源性致炎因子TNF—a、IL-6显著下降，血浆免疫球蛋白IgG、IgM明显上升，差异有统计学意义（P〈0．05）。结论：奥曲肽对急性胰腺炎有明显的抗炎作用，并能上调患者的免疫功能，有益于急性胰腺炎的治疗。

Anti--inflammatory and immunoregulatory effect of octreotide on acute pancreatitis

Objective：To investigate the effect of octreotide on the anti--inflammation and immunoregula- tion for patients with acute pancreatitis. Methods： A total of 60 patients with acute pancreatitis were ran- domly divided into experimental group （n=30） and control group （n=30）. The patients in control group were treated with conventional treatment, and those in experimental group were treated with the conven- tional treatment and intravenous octreotide injection. Results： Compared with control group, the endogenic inflammatory factors including serum TNF--a and IL--6 were significantly decreased and the immunoglob- ulin including IgG and IgM were significantly increased inexperimental group （P〈0.05）. Conclusion： Oct- reotide has obvious anti--inflammatory effect and could up--regulate the immune function, which is help- ful for the treatment of acute pancreatitis.