卵巢上皮癌组织Id-1和HO-1表达及临床意义

目的探讨分化抑制因子-1（Id-1）和血红素加氧酶-1（HO-1）在卵巢上皮癌组织中的表达及其与临床病理参数的关系。方法采用免疫组化S-P法,检测50例卵巢上皮癌、45例良性卵巢肿瘤及15例正常卵巢组织中Id-1和HO-1的表达。结果卵巢癌组织中Id-1和HO-1的阳性表达率明显增高,与良性卵巢瘤组织比较,差异有显著性（χ2=17.083、6.838,P〈0.05）;与卵巢正常组织比较,差异有显著性（χ2=31.097、27.444,P〈0.05）。Id-1、HO-1在卵巢上皮癌组织中的表达与术前CA125水平、病理分级和淋巴结转移密切相关（χ2=4.678-7.739,P〈0.05）。卵巢上皮癌组织中Id-1和HO-1的表达呈正相关（r=0.390,P〈0.05）。结论 Id-1和HO-1的高表达在卵巢上皮癌的发生、发展中起重要作用。

THE EXPRESSIONS OF ID-1 AND HO-1 IN EPITHELIAL OVARIAN CARCINOMA AND CLINICAL SIGNIFICANCE

Objective To investigate the expressions of inhibitor of differentiation protein 1（Id-1）and heme oxygenase-1（HO-1）in tissue of epithelial ovarian carcinoma（EOC）and their correlation with clinicopathological parameters. Methods The expressions of Id-1and HO-1were determined by immunohistochemical SP method in 50 cases of EOC,45 cases of benign ovarian tumor and 15 cases of normal ovarian tissue. Results The positive rate of Id-1and HO-1in EOC tissue markedly elevated,the differences were significant as compared with benign ovarian tumors（χ2=17.083,6.838;P〈0.05）and normal ovarian tissue（χ2=31.097,27.444;P〈0.05）.The expressions of Id-1and HO-1in EOC were associated with the levels of CA125 before surgery,pathology grading and 1ymph node metastasis（χ2=4.678-7.739,P〈0.05）.The expression of Id-1in tissue of EOC was positively correlated with HO-1（r=0.390,P〈0.05）. Conclusion The high expressions of Id-1and HO-1play an important role in the carcinogenesis and development of EOC.