| PD-1/PD-L与脓毒症诱导的急性肺损伤关系的研究进展 |
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| 引用本文： | 程婷婷,李红强,白建文. PD-1/PD-L与脓毒症诱导的急性肺损伤关系的研究进展[J]. 同济大学学报(医学版), 2014, 35(5): 128-132 |
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| 作者姓名： | 程婷婷 李红强 白建文 |
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| 作者单位： | 同济大学附属东方医院急诊内科,上海200120 |
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| 基金项目： | 上海市浦东新区科技发展基金创新资金（PKJ2010-Y20） |
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| 摘 要： | 脓毒症诱导的急性肺损伤发病率高、病死率高,目前可应用的治疗方法有限,且效果欠佳。程序性细胞死亡受体-1（Programmed Cell Death-1,PD-1）及其配体PD-L在脓毒症诱导的急性肺损伤中具有重要作用,可以改变免疫细胞及细胞因子的数量和功能,并影响疾病预后。本文就PD-1/PD-L与脓毒症诱导的急性肺损伤的研究进行综述。
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| 关 键 词： | 共抑制受体 急性呼吸窘迫综合征 固有免疫 巨噬细胞 细胞因子 凋亡 |
PD-1 / PD-L and sepsis-induced acute lung injury |
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| CHENG Ting-ting,LI Hong-qiang and BAI Jian-wen. PD-1 / PD-L and sepsis-induced acute lung injury[J]. Journal of Tongji University(Medical Science), 2014, 35(5): 128-132 |
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| Authors: | CHENG Ting-ting LI Hong-qiang BAI Jian-wen |
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| Affiliation: | (Dept. of Emergency Internal Medicine, East Hospital, Tongji University, Shanghai 200120, China) |
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| Abstract: | Sepsis-induced acute lunginjury is associated with high morbidity and mortality,however,the therapy for this disease is limited and less effective. Programmed cell death-1（ PD-1） and its ligand PD-L has been identified toaffect the cellular and cytokine profiles and modify the disease prognosis,it would be a potential therapeutic modality for sepsis-induced acute lunginjury. The relationship between PD-1 / PD-L and sepsis-induced acute lunginjury is discussed in this review. |
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| Keywords: | co-inhibitory receptor acute respiratory distress syndrome innate immunology macrophage cytokine apoptosis |
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