| 非瓣膜病性心房颤动患者血清CRP BNP与ET-1水平的测定及其临床意义 |
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| 引用本文： | 饶志荣,杨友祥,王宁生,方快发,刘文兵,张亦辉,林佩环.非瓣膜病性心房颤动患者血清CRP BNP与ET-1水平的测定及其临床意义[J].河北医学,2012,18(2):166-168. |
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| 作者姓名： | 饶志荣 杨友祥 王宁生 方快发 刘文兵 张亦辉 林佩环 |
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| 作者单位： | 广东省惠州市惠阳区人民医院心内科,广东 惠州,516211 |
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| 摘 要： | 目的:探讨非瓣膜病性心房颤动(AF)患者血清反应蛋白(CRP)、脑钠肽(BNP)与内皮素-1(ET-1)的水平变化及其临床意义。方法:选择持续性房颤患者58例,同时选择性别、年龄、病情等与之相匹配的窦性心律心脏病患者(窦性心律组)55例,测定血清CRP、BNP、ET-1水平并进行统计分析。结果:AF组患者CRP、BNP及ET-1水平均显著高于窦性心律组,差异均具有统计学意义(P<0.01);在相同心功能亚组中,AF组CRP、BNP及ET-1水平均显著高于窦性心律组(P<0.01或P<0.05),且以上指标均随着心功能分级的升高而升高。结论:AF患者血清CRP、BNP及ET-1水平明显升高,并随着心衰程度的加重而升高。
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| 关 键 词： | 心房颤动 C-反应蛋白 脑钠肽 内皮素-1 |
The Detection and Clinical Value of Serum CRP Brain Natriuretic Peptide and Endothelin-1 in Patients with Nonvalvular Atrial Fibrillation |
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| Institution: | RAO Zhirong,YANG Youxiang,WANG Ningsheng,et al(The People’s Hospital in Huiyang District of Huizhou,Guangdong Huizhou 516211,China) |
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| Abstract: | Objective: To investigate the level changes and clinical value of serum-reactive protein(CRP),brain natriuretic peptide(BNP) and endothelin-1(ET-1) in patients with nonvalvular atrial fibrillation(AF). Method: 58 patients with AF were included,and selected 55 patients with sinus rhythm who matched with them in gender,age,illness,etc.The levels of serum CRP,BNP,ET-1 were statistically analyzed. Result: The levels of CRP,BNP and ET-1 in AF group were significantly higher than in the sinus rhythm group(P <0.01);In the same cardiac function subgroup,the levels of CRP,BNP and ET-1 were significantly higher in the AF group than in the sinus rhythm group(P <0.01 or P <0.05),and the above indicators increased with the increase of severity of cardiac function. Conclusion:The levels of serum CRP,BNP and ET-1 in the patients with AF are significantly higher with more serious of cardiac failure. |
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| Keywords: | Atrial fibrillation C-reactive protein Brain natriuretic peptide Endot helin-1 |
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