妊娠期肝内胆汁淤积症对围生儿预后的影响分析

目的:探讨妊娠期肝内胆汁淤积症(ICP)对围生儿预后的影响,分析其对围生儿的危害.方法:选择我院2005年1月至2010年9月在我科住院分娩的ICP孕妇164例进行回顾性分析,选择同期住院分娩的非ICP孕妇164例做为对照组.结果:ICP孕妇胎儿宫内窘迫、新生儿窒息、早产发生率、围生儿死亡率均较非ICP孕妇高,其差异均有统计学意义(P＜0.001或0.01)；两组新生儿吸入性肺炎及小于胎龄儿发生率无明显差异,无统计学意义(P＞0.05).结论:妊娠期ICP严重影响围生儿的预后,应做到早期诊断、早期治疗,适时终止妊娠,降低ICP对围生儿的危害.

Analysis of Perinatal Prognosis Factor of Intrahepatic Cholestasis During Pregnancy

Objective: To study the factor affecting the perinatal prognosis in intrahepatic chotestasis of pregnancy(ICP). Method: 220 patients from Jan.2005 to Sep.2010 in our hospital delivery with ICP were retrospectively analyzed,and chose 220 pregnant women without ICP at the same time earlier hospital delivery as control groups. Result: The control group of the fetal distress,neonatal asphyxia,the incidence of preterm birth,and perinatal mortality were lower than in ICP pregnant women,the differences were statistically significant(P<0.001 or 0.01).while,there was no significant diffrence in the ratio of inhalation pneumonia of newborn and SGA between the two groups(P>0.05). Conclusion: ICP serious impact on perinatal prognosis,should achieve early diagnosis and early treatment,timely termination of pregnancy,decreased ICP on perinatal hazards.