| 恩替卡韦治疗慢性乙型肝炎124例疗效观察 |
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| 引用本文： | 姜涛,涂尚成.恩替卡韦治疗慢性乙型肝炎124例疗效观察[J].河北医学,2012,18(7):942-945. |
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| 作者姓名： | 姜涛 涂尚成 |
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| 作者单位： | 1. 广东省深圳市宝安区福永人民医院,广东,深圳,518000
2. 广东省深圳市第六人民医院感染科,广东,深圳,518000 |
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| 摘 要： | 目的:探讨恩替卡韦治疗慢性乙型肝炎疗效。方法:选择240例患者进行研究,按照治疗方法不同分为实验组和对照组,采用SPSS13.0统计软件进行统计分析。结果:实验组与对照组HBeAg阴转率在各时间段比较不存在统计学意义(P>0.05),HBeAg阴转率实验组和对照组均在治疗后24周、治疗后48周分别与前一个观察时间段比较存在统计学意义(P<0.05),实验组与对照组HBV-DNA阴转率、血清ALT复常率、血清AST复常率在各时间段比较均存在统计学意义(P<0.05),HBV-DNA阴转率、血清ALT复常率、血清AST复常率实验组和对照组均在治疗后12周、治疗后24周、治疗后48周分别与前一个观察时间段比较存在统计学意义(P<0.05)。结论:采用恩替卡韦治疗慢性乙型肝炎疗效快速、安全性高且耐药率低。
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| 关 键 词： | 慢性乙型肝炎 恩替卡韦 拉米夫定 |
Clinical Observation of Entecavir in Treating 124 Cases Chronic Hepatitis B |
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| Institution: | JIANG Tao,et al(Fuyong People’s Hospital in Baoan District of Shenzhen, Guangdong Shenzhen 518000,China) |
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| Abstract: | Objective: To study entecavir in treating chronic hepatitis.Method: 240 cases of patients were studied,according to the different treatment methods,were divided into experimental group and control group,compared the effect of 2 groups.Result: HBeAg negative conversion rate in the experimental group and the control group were in the 24 weeks after treatment,after treatment and after 48 weeks respectively,and a comparison of observed time statistical significance(P < 0.05),the experimental group and the control group of HBV-DNA negative conversion rate,serum ALT recovery rate,serum AST recovery rate in the time comparisons were statistically significant(P < 0.05).Conclusion: The use of entecavir in treating chronic hepatitis B with fast,high safety and low resistance rate. |
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| Keywords: | Chronic hepatitis B Entecavir Lamivudine |
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