原发性高血压昼夜血压节律与动态动脉硬化指数踝肱指数的关系

目的:探讨原发性高血压患者昼夜血压节律变化与动态动脉硬化指数、踝肱指数的关系。方法:根据动态血压监测血压昼夜节律的变化,将759例原发性高血压患者分为杓型组190例,非杓型组204例,超杓型组186例,反杓型组179例,分别计算各组动态动脉硬化指数,并进行踝肱指数测量。结果:动态动脉硬化指数:反杓型组>非杓型组>超杓型组>杓型组,各组比较有统计学意义(P<0.05);踝肱指数:杓型组=超杓型组>非杓型组>反杓型组,杓型组、超杓型组与非杓型组、反杓型组比较有统计学意义(P<0.05)。结论:血压昼夜节律异常是影响动态动脉硬化指数及踝肱指数的重要因素,恢复正常血压昼夜节律对防治动脉硬化及靶器官保护具有重要临床意义。

Relationship between Circadian Rhythm and Ambulatory Arterial Stiffness Index and Ankle-brachial Index in Patients with Essential Hypertension

Objective: To investigate the relationship between circadian rhythm and ambulatory arterial stiffness index(AASI),and ankle-brachial index(ABI) in patients with essential hypertension.Method: According the results of ambulatory blood pressure monitoring,essential hypertension patients were divided into dipper blood pressure group(n=190),non-dipper group(n= 204),ultra-dipper group(n=186) and anti-dipper group(n=179).AASI was calculated and ABI was measured.Result: AASI: anti-dipper group> non-dipper group> ultra-dipper group >dipper group.AASI among all groups had significant differences(all P<0.05);ABI: dipper group= ultra-dipper group > non-dipper group > anti-dipper group.ABI had significant differences between dipper group,ultra-dipper group and non-dipper group,anti-dipper group(P<0.05).Conclusion: Abnormal circadian rhythm of blood pressure and AASI and ABI are closely related.Restoring of circadian rhythm of blood pressure is effective in prevention and treatment of atherosclerosis and target organ damage.