| 幽门螺杆菌与胃癌 |
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| 引用本文： | 孙波,杨骅,屠振兴,李兆申. 幽门螺杆菌与胃癌[J]. 第二军医大学学报, 2003, 24(12): 1356-1358 |
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| 作者姓名： | 孙波 杨骅 屠振兴 李兆申 |
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| 作者单位： | 第二军医大学长海医院消化内科,上海,200433 |
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| 基金项目： | 国家自然科学基金(30170427) |
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| 摘 要： | 幽门螺杆菌(Hp)感染与胃癌的发生密切相关，其分子机制非常复杂，可能通过多个途径的调节而发生。动物模型的建立为阐明Hp感染在胃癌发生中的作用奠定了基础。本文就近年来该领域流行病学、动物模型、分子发病机制等研究作一综述。
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| 关 键 词： | 幽门螺杆菌感染 胃癌 发病机制 动物模型 流行病学 |
| 文章编号： | 0258-879X(2003)12-1356-03 |
| 修稿时间： | 2003-06-30 |
Helicobacter pylori and gastric carcinoma |
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| SUN Bo,YANG Hua,TU Zhen-Xing,LI Zhao-Shen. Helicobacter pylori and gastric carcinoma[J]. Former Academic Journal of Second Military Medical University, 2003, 24(12): 1356-1358 |
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| Authors: | SUN Bo YANG Hua TU Zhen-Xing LI Zhao-Shen |
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| Abstract: | Helicobacter pylori(Hp) infection plays an important role in the development of gastric carcinoma. Colonization of CagA-positive Hp is a great risk for intestinal gastric carcinoma. The mechanism of Hp infection changing the gastric epithelium at the molecular level is complex and through multiple pathways. Animal models can be of great help in exploring the role of Hp infection in gastric cancer development. This paper reviewed the latest studies of epidemiology, animal model and molecular pathogenesis of Hp associated gastric cancer. |
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| Keywords: | Helicobacter pylori stomach neoplasms review literature |
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