Influence of endothelial dysfunction on telomere length in subjects with metabolic syndrome: LIPGENE study |
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Authors: | Lorena González-Guardia Elena María Yubero-Serrano Oriol Rangel-Zuñiga Carmen Marin Antonio Camargo Pablo Pérez-Martínez Javier Delgado-Lista Francisco Gómez-Delgado Antonio Garcia-Rios Francisco José Tinahones Helen M. Roche Francisco Pérez-Jiménez José López-Miranda |
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Affiliation: | 1. Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, Avda. Menendez Pidal, s/n., 14004, Córdoba, Spain 2. CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain 3. Division of Experimental Diabetes and Aging, Department of Geriatrics and Palliative Care, Mount Sinai School of Medicine, New York, USA 4. Biomedical Research Laboratory, Endocrinology Department, Hospital Virgen de la Victoria, Malaga, Spain 5. Nutrigenomics Research Group, School of Public Health and Population Science, UCD Conway Institute, University College Dublin, Dublin, Ireland
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Abstract: | Previous evidences support that increased oxidative stress (OxS) may play an important role in metabolic syndrome (MetS) and both are closely linked to vascular dysfunction. This study determined whether there is a relationship between endothelial function and relative telomere length (RTL) in MetS subjects. In this cross-sectional study from the LIPGENE cohort, a total of 88 subjects (36 men and 52 women) were divided into four groups by quartiles of telomere length. We measured ischemic reactive hyperemia (IRH), total nitrite (NO) and protein carbonyl (PC) plasma levels, F2-isoprostanes urinary levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. IRH and NO plasma levels were higher in subjects with longer RTL (quartiles 3 and 4), while PC plasma levels, F2-isoprostanes urinary levels, and GPx and SOD plasma activities were lower in quartile 4 subjects (longest RTL). Additionally, MetS subjects with longer RTL had greater homeostatic model assessment-β level and lower triglycerides plasma levels. Our results suggest that endothelial dysfunction, associated with high levels of OxS, could be entailed in an increment of telomere attrition. Thus, further support of the molecular and cellular mechanisms involved in vascular dysfunction may contribute to the development of strategies to decelerate vascular aging or prevent cardiovascular disease. |
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Keywords: | Endothelial dysfunction LIPGENE study Metabolic syndrome Oxidative stress Telomeres |
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