Inhibitors of inducible nitric oxide synthase expression from<Emphasis Type="Italic">artemisia iwayomogi</Emphasis> |
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Authors: | Hanna?Ahn Ji?Yeon?Kim Hwa?Jin?Lee Yong?Kyun?Kim Email author" target="_blank">Jae-Ha?RyuEmail author |
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Institution: | College of Pharmacy, Sookmyung Womens University, Seoul 140-742, Korea. |
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Abstract: | Nitric oxide (NO) is an important bioactive agent that mediates a wide variety of physiological and pathophysiological events. NO overproduction by inducible nitric oxide synthase (iNOS) results in severe hypotension and inflammation. This investigation is part of a study to discover new iNOS inhibitors from medicinal plants using a macrophage cell culture system. Two sesquiterpenes (1 and 2) were isolated from Artemisia iwayomogi (Compositae) and were found to inhibit NO synthesis (IC50 3.64 microg/mL and 2.81 microg/mL, respectively) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Their structures were identified as 3-O-methyl-isosecotanapartholide (1) and iso-secotanapartholide (2). Compounds 1 and 2 inhibited the LPS-induced expression of the iNOS enzyme in the RAW 264.7 cells. The inhibition of NO production via the down regulation of iNOS expression may substantially modulate the inflammatory responses. |
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Keywords: | Artemisia iwayomogi Nitric oxide synthase Sesquiterpene Inhibitor |
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