Ocular microbiota and polymorphonuclear leucocyte recruitment during overnight contact lens wear |
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| Authors: | F Stapleton PhD MDP Willcox PhD N Sansey BSc BA Holden PhD |
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| Affiliation: | Cornea and Contact Lens Research Unit, School of Optometry and Cooperative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, New South Wales, Australia |
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| Abstract: | Bacterial colonization of the ocular surface and contact lens (CL) and recruitment of polymorphonuclear leucocytes (PMN) during overnight CL wear was examined in I I asymptomatic wearers. The ocular surface was more frequently colonized than the CL with commensal bacteria (W0.05). Following sleep, more bacteria were recovered from the CL compared with daily use (P<0.05), and fewer PMN were recruited compared t o sleep without CL wear (Plt;0.05). Overnight CL wear may inhibit physiological PMN recruitment t o the cornea by preventing their access, by modifying the chemotactic signal o r by altering the activation state ofthe recruited cells. |
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| Keywords: | bacteria conjunctiva contact lens lid polymorphonuclear leucocyte |
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