急进高原过程中飞行应激对大鼠生理生化指标的影响研究

目的 考察急进高原过程中飞行应激对大鼠生理生化指标的影响。方法 在从平原（上海）飞行急进高原（玛多）的同时，采取从平原（上海）飞行急进平原（西安）的实验对照，比较血气指标和生化指标的差异。结果 急进玛多组与上海组相比，门冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶、血清尿素氮、血清尿酸、葡萄糖、总蛋白分别升高了1.30倍、1.17倍、17.91%、52.27%、3.31倍、97.61%、29.75%（P<0.01）；乳酸脱氢酶、肌酐分别下降了68.16%与48.21%（P<0.01）；缓冲碱、碱剩余、动脉血二氧化碳分压、动脉血氧饱和度、动脉血氧分压分别降低了2.07倍、3.80倍、29.76%、7.42%、43.29%（P<0.05或P<0.01）；红细胞积压、总血红蛋白浓度、血清钠离子浓度、血清氯离子浓度分别升高9.30%，8.57%，2.36%，10.24%（P<0.05）。急进平原组和平原组两组间各指标无显著性差异。结论 飞行应激对于大鼠生理生化指标的影响无统计学差异，采用飞行急进高原的实验模型研究高原缺氧对药动学的影响理论上可行。

Study of Flight Stress at High Altitude on Physiological and Biochemical Indexes in Rats

OBJECTIVE To investigate the effect of flight stress on the physiological and biochemical parameters of rats in the processes of acute expose to high altitude. METHODS To compare the difference of physiological and biochemical parameters between flying from plain area (Shanghai) to plain area (Xi''an) and to high plateau (Ma Do). RESULTS Compared with Shanghai group, the aspartate aminotransferase, alanine aminortransferase, alpaline phosphatase, urea nitrogen, uric acid, glucose, total protein of acute exopose to MaDo group were significantly increased 130%, 117%, 17.91%, 52.27%, 331%, 97.61% and 29.75%(P<0.01). While lactate dehydrogenase, creatinine were significantly reduced 68.16% and 48.21% after acute exposed from plain area to high altitude(P<0.01). The hematocritg, concentration of total hemoglobin, serum sodium, serum chlorine were significantly increased 9.30%, 8.57%, 2.36% and 10.24% while buffer base, buffuer excess, carbon dioxide tension of arterial blood, oxygen saturation of arterial blood, oxygen tension of arterial blood were significantly reduced 207%, 380%, 29.76%, 7.42%, 43.29% after acute exposed from plain area to high altitude(P<0.05 or P<0.01). The indicators after acute exposed from plain area to plain area were insignificantly on statistics. CONCLUSION Flight stress has no effect on the physiological and biochemical parameters of rats in the progress of acute expose to high altitude, it can molding an experimental model by acute flying from plain area to high altitude to investigate the hypoxia effects on pharmacokinetics.