国产美罗培南治疗多重耐药菌感染的临床观察

目的评价美罗培南治疗多重耐药菌感染的临床疗效,并与亚胺培南/西司他丁进行比较. 方法采用随机对照实验设计,观察美罗培南与亚胺培南/西司他丁治疗49例,经多种抗菌药物治疗无效伴多重耐药菌感染的临床疗效及不良反应. 结果国产美罗培南组24人,有效率95.8%,治愈率79%,细菌清除率79%;亚胺培南/西司他丁25人,有效率96%,治愈率80%,细菌清除率80%,两组间疗效相当,无明显不良反应. 结论国产美罗培南对多种抗菌药物治疗无效的多重耐药菌感染有良好的疗效,不良反应发生率低,具有较高的临床应用价值.

Domestic Meropenem in Treatment of Infection for Multi-drug Resistant Bacteria: A Clinical Study

OBJECTIVE To evaluate and compare the effect between domestic meropenem and imipenem on infection for multit-drug resistant bacteria. METHODS A randomized,open-label,controlled study was conducted to observe patients with infection for multi-drug resistant bacteria.A total of 49 hospitalized patients were enrolled in the study.From them 24 patients received meropenem 1.0g every 12 hours(or 1.0g every 8 hours if necessary)intravenously,25 patients received imipenem 1.0g every 12 hours(or 1.0g every 8 hours if necessary)intravenously. RESULTS The efficacy rate of meropenem group was 95.8%,and its cure rate was 79%,the bacterial eradication rate was 79%.The efficacy rate of imipenem group was 96%,and its cure rate was 80%,the bacterial eradication rate was 80%.There was not significant difference between two groups.The rate of adverse reactions for both meropenem and imipenem was low. CONCLUSIONS Domestic meropenem shows significant antimicrobial activity for multi-drug resistant bacteria,and it has a high clinical value.