胃舒胶囊治疗萎缩性胃炎癌前病变的临床研究

目的：探讨胃舒胶囊对萎缩性胃炎癌前病变的治疗作用及机理。方法：７５例萎缩性胃炎癌前病变患者随机分为两组，治疗组（４５例）给予胃舒胶囊口服，对照组（３０例）给予胃宁冲剂冲服，疗程均为６个月。观察两组患者临床、病理疗效，治疗前后萎缩，肠化，异型增生，肠化亚型和癌胚抗原（ＣＥＡ），增殖细胞核抗原（ＰＣＮＡ）表达积分值的变化。结果：治疗组临床总有效率为９１％，对萎缩，肠化，异型增生的有效率分别为６４％、６

Clinical Study of Weishu Capsule in Treating Precancerous Lesions of Chronic Atrophic Gastritis

Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC) in treating precancerous lesions of chronic atrophic gastritis (CAG). Methods: Seventy five cases of precancerous lesions of CAG were distributed to two groups randomly, the treated group (45 patients) treated with WSC by taken orally and the control group (30 patients) treated with Weining granule (WNG) orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores of atrophy, intestinal metaplasia and its subgroups, dysplasia, carcinoembryonic antigen (CEA) and proliferating cell nuclear antigen (PCNA) expression were observed before and after treatment. Results: The total effective rate was 91% and the effective rate of atrophy, intestinal metaplasia, dysplasia in the treated group were 64%, 67% and 65% respectively, and the respective scores were lowered significantly after treatment. Compared with the control group, the difference between the two groups was statistically significant (P<0 01,P<0 05). Immunohistochemical test showed that WSC could inhibit the subgroups of intestinal metaplasia, CEA and PCNA expression significantly (P<0 01). Conclusion: WSC could significantly improve the clinical and pathological changes in the precancerous lesions of CAG. The mechanism might be related to the inducing and promoting effect of WSC on the differentiation and maturity of intestinal metaplasia cells and dysplasia cells. WSC could also inhibit and correct the abnormal proliferation of cells.