补阳还五汤对大鼠动脉血栓形成前后动脉血中血小板活？…

目的：探讨补阳还五汤一次和连续灌服给药对大鼠实验性动脉血栓形成前后动脉血中血小板活化因子（ＰＡＦ）含量的影响。方法：将雄性Ｗｉｓｔａｒ大鼠分别随机分为３组。用药组一次或连续（１４天，每天１次）灌服补阳还五汤水煎液（３２ｇ／ｋｇ，１６ｇ／ｋｇ），对照组一次或连续（１４天，每天１次）灌服地塞米松片溶液（１ｍｇ／ｋｇ、０．５ｍｇ／ｋｇ）；空白组均灌服等体积蒸馏水（１０ｍｌ／ｋｇ）。末次给药２ｈ后，复制实

Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]

OBJECTIVE: To explore the effect of Buyang Huanwu Decoction (BHD) on arterial blood platelet factor (PAF) content in pre- and post-arterial thrombosis of rats. METHODS: Male Wistar rats were randomized into 3 groups, the BHD group treated with BHD 32 g/kg, or with BHD 16 g/kg daily for 14 days consecutively, the control group treated with dexamethasone 0.5-1 mg/kg and the blank group treated with distilled water 10 ml/kg. Arterial thrombosis was duplicated in the animals 2 hours after final medication, the blood content of PAF (by bioassay), dry weight (W) and occlusion time (OT) of thrombus, and weight of thrombus/body weight (TW/BW) ratio were observed. RESULTS: Consecutive BHD treatment could markedly lower the arterial blood content of PAF after thrombosis, increase the OT value of thrombus, reduce the dry weight of thrombus and the TW/BW ratio (P < 0.05), while no influence was found in rats treated with BHD once. CONCLUSIONS: BHD has certain antagonistic effect on pathologic PAF metabolism, and inhibitory effect on pathogenesis and development of arterial thrombosis.