| 芫花对未孕大鼠离体子宫平滑肌条作用的研究 |
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| 引用本文： | 马永明,刘恒,瞿颂义,邱小青,张英福,丁永辉,卫玉玲. 芫花对未孕大鼠离体子宫平滑肌条作用的研究[J]. 中国中药杂志, 1998, 23(7): 429-430 |
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| 作者姓名： | 马永明 刘恒 瞿颂义 邱小青 张英福 丁永辉 卫玉玲 |
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| 作者单位： | 兰州医学院生理教研室 兰州 730000;甘肃省药品检验所中草药室 兰州 730000 |
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| 基金项目： | 甘肃省科委自然科学基金 |
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| 摘 要： | 目的:观察芫花根皮水煎剂对人工动情期大鼠离体子宫平滑肌条的作用,以探讨其作用机理。方法:将离体子宫平滑肌条悬挂于离体平滑肌灌流肌槽装置内,采用分离加药的方法以观察结果。结果:芫花根皮水煎剂可兴奋大鼠离体子宫平滑肌并有剂量依赖性关系;阿托品、酚妥拉明、六烃季胺、苯海拉明不能阻断芫花兴奋大鼠离体子宫平滑肌的作用;异搏定可完全阻断芫花兴奋大鼠离体子宫平滑肌的作用,前列腺素合成酶抑制剂消炎痛可使芫花的兴奋作用降低。结论:芫花对未孕大鼠离体子宫平滑肌条的兴奋作用,可能是通过作用于平滑肌细胞膜的Ca2+通道和部分刺激前列腺素合成、释放的途径实现的。
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| 关 键 词： | 芫花 离体子宫平滑肌 前列腺素 异搏定 抗早孕 |
| 收稿时间： | 1997-09-09 |
Effect of Yuanhua on Isolated Uterine Strips in Unpregnant Rats |
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| Y Ma,H Liu,S Qu,X Qiu,Y Zhang,Y Ding,Y Wei. Effect of Yuanhua on Isolated Uterine Strips in Unpregnant Rats[J]. China Journal of Chinese Materia Medica, 1998, 23(7): 429-430 |
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| Authors: | Y Ma H Liu S Qu X Qiu Y Zhang Y Ding Y Wei |
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| Affiliation: | Department of Physiology, Lanzhou Medical College, Lanzhou 730000. |
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| Abstract: | OBJECTIVE: To explore the mechanism on the effect of Yuanhua on the contractile activity of isolated uterine strips in rats under artificial oestrum. METHOD: Isolated strips were suspended in a tissue chamber in which Yuanhua was added with some antagonists of inhibitors or without. RESULT: Yuanhua could excite the uterine smooth muscle strips in a dose-dependent manner, but atropine, phentolamine, hexamethonium and diphenhydramine could not inhibit this exciting action. This exciting effect could be inhibited completely by verapamil and decreased by indomethacin(inhibitor of prostaglandin synthase). CONCLUSION: The exciting effect of Yuanhua on un-pregnant rats in vitro might be related to an action on the cell membrane Ca2+ channel as well as to a partial stimulation of synthesis and release of PG. |
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| Keywords: | Yuanhua uterine muscle strips prostaglandin verapamil anti-early-pregnant |
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