乌龙丹治疗急性脑梗塞及对下丘脑—垂体—甲状腺轴内分泌激素变化的影响

目的：通过对６６例急性脑梗塞住院患者进行了较系统的临床观察和有关下丘脑－垂体－甲状腺轴内分泌激素水平的检测，以探讨中药复方乌龙丹的临床疗效和有关机制。方法：临床疗效评定采用计分法，治疗组（３５例）用低分子右旋糖酐静脉滴注加乌龙丹口服。对照组（３１例）用低分子右旋糖酐静脉滴注加尼莫通口服，疗程均为４周，治疗前后采血用放免法检查：三碘甲状腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）、游离三碘太腺原氨酸（ＦＴ３）

Effect of Wulong Dan on Treatment of Acute Cerebral Infarction and Change of Hormones in Hypothalamus Pituitary Thyroid Axis

OBJECTIVE: To explore the effect of Wulong Dan (WLD) on treatment of acute cerebral infarction and change of hormones in hypothalamus-pituitary-thyroid axis. METHODS: Thirty five cases of the treated group treated with WLD by taken orally and 31 cases of the control group treated with nimoton taken orally. And dextran was given intravenously to both groups. Blood level of triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), free thyroxine (FT4) and thyroid stimulating hormone (TSH) of all patients were determined before and after treatment by radioimmunoassay. RESULTS: After 4 weeks of treatment, there were significant difference between the treated group and the control group in cure rate, markedly effective rate, cure score and disappearance of clinical symptoms (P < 0.01). The levels of T3, FT3, TSH of all patients were lower than those of the normal control before treatment. After treatment with WLD and dextran, the above-mentioned indexes turned to normal. CONCLUSIONS: WLD has a significant effect on patients with cerebral infarction on the basis of improved microcirculation induced by dextran. It also has regulatory effect on the hypothalamus-pituitary-thyroid axis disorder so as to be helpful in maintaining the homeostasis.