99mTc-ECD SPECT脑功能显像检测干燥综合征并发中枢神经系统损害异常rCBF 29例临床分析

目的探讨99mTc-ECDSPECT脑功能显像检测干燥综合征(SS)异常脑血流改变的临床价值。方法对19例SS伴发中枢损害症状或体征的患者进行99mTc-ECDSPECT脑功能显像,以10例SS无确切中枢损害症状或体征者作为对照组。结果19例SS伴发中枢损害患者99mTc-ECDSPECT脑功能显像检测出11例(57·9%)局部脑血流灌注(rCBF)减低,对照组仅1例(10·0%)rCBF减低,两组间差异有显著性意义(χ2=6·20,P<0·05)。最常被累及的区域为顶叶、颞叶。结论可以用99mTc-ECDSPECT脑功能显像检测SS伴发中枢损害患者的脑血流灌注减低。但该方法确切的灵敏度及特异性尚需进一步探讨。

Sjogren′s Syndrome Complicated with Regional Cerebral Blood Flow Disturbance Detected by 99mTc-ECD SPECT: A Clinical Analysis of 29 Patients

Objective To investigate the clinical value of Technetium-99m-ethyl cysteinate dimmer (~ 99m Tc-ECD) single photon emission computed tomography (SPECT) in detecting the changes of regional cerebral blood flow (rCBF) of patients with Sjogren's syndrome (SS).Methods ~ 99m Tc-ECD brain SPECT was performed to detect the rCBF of 19 patients with SS complicated with brain lesions, and 10 patients with SS with no certain brain lesion as control.Results ~ 99m Tc-ECD SPECT showed,, in 11 (57.9%) of the 19 trial patients, while in only one (10.0%) of the 10 patients, there was hypoperfusion of rCBF, with a significant difference (P<0.05), and the parietal and temporal lobes were the most common areas with such lesions.Conclusion This study suggests that ~ 99m Tc-ECD SPECT is an effective tool for detecting hypoperfusion of rCBF in patients with SS. However, the exact sensitivity and specificity of this method needs to be further explored.