纳洛酮联合甲泼尼龙佐治难治性毛细支气管炎疗效观察

目的 观察纳洛酮联合甲泼尼龙(MPS)佐治难治性毛细支气管炎的疗效.方法 将98例难治性毛细支气管炎住院患儿随机分为治疗组(56例)和对照组(42例),治疗组在常规治疗基础上加用纳洛酮及MPS.结果 根据咳、喘及肺部体征,治疗组48h及5d平均积分明显低于对照组,有显著性差异(P＜0.001),且其总有效率(87.5%)与对照组(38.1%)比较有显著性差异(x2=26.23,P＜0.01).结论 纳洛酮联合MPS佐治难治性毛细支气管炎效果好.

Effects of Naloxone and Methylprednisolone on therapy of severe bronchiolitis

Objective To observe the clinical effects of Naloxone and Methylprednisolone(MPS) on therapy of severe bronchiolitis. Methods 98 cases of severe bronchihtis were randomly divided into 2 groups,the Naloxone/MPS treating group and the control group,the later only give regular treatment. Results The Naloxone/MPS treating group scored significantly lower at the time of 48 hours and 5 days(P＜0.001),according to cough,dyspnia and other respiratory symptoms,and the efficacy of Naloxone/MPS treatment is appreciately higher than control(P＜0.01). Conclusion Naloxone and MPS therapy shows remarkable clinical beneficial effects on severe bronchiolitis.