脑组织质子磁共振波谱成像

目的 :探讨质子磁共振波谱成像 (1 HMRSI)的临床应用价值。方法 :Marconi1.5T磁共振PRESS序列波谱成像 ,其中正常人 4例 ,大面积脑梗塞 6例 ,脑肿瘤 6例 ,分析波谱成像所能提供的代谢物信息。结果 :质子磁共振波谱成像不仅能检测到病变中心 ,也可以检测到病变周围代谢物的变化。正常人群脑组织两侧代谢物分布对称 ,同侧不同部位代谢物空间分布不同 ;大面积缺血性脑梗塞不同时期代谢物变化不同 ,病灶中心及周围代谢物分布也不均衡 ,反映了组织的损伤程度不同、缺血半暗带存在等 ;不同肿瘤具有不同的代谢物变化特征 ,肿瘤中心及周围代谢物浓度也并非均匀一致 ,反映了肿瘤组织不同的病理性质及其病变程度。结论 :1 HMRSI是一种安全的非侵袭性的、能得到较大兴趣区多体素波谱及其代谢物空间分布图的方法 ,具有较高的空间分辨率 ,可以成为一种结构成像的波谱研究方法

The Clinical Application of 1 HMRSI in Brain

Objective: To study the clinical application of 1 HMRSI in Brain. Methods: Normal group (n=4), greater ischemic cerebral infarcts group(n=6) and cerebral tumors group(n=6) were examined in PRESS sequence of Marconi 1.5 T instrument and the metabolic information was analyzed. Results: 1 HMRSI could show not only the lesion center metabolic change but also the lesion circumstance metabolic alteration. The normal group bilateral metabolites were symmetric, but not even in one hemisphere. In the greater ischemic cerebral infarcts metabolites were differently changed with various phases. The metabolic distribution was different in the lesion center and circumstance. It illustrated the different tissue injury, ischemic penumbra and so on. Different tumors had different metabolic characters. The metabolic distribution of tumors was not balanced in both lesion center and circumstance. It implied the different pathologic nature and degree of the tumors. Conclusion: 1 HMRSI is a non invasive method that can obtain multivoxel spectroscopy and the metabolic maps. It is a high spatial resolution and structural imaging way of spectroscopic study.