甲泼尼龙、泼尼松序贯疗法对原发性肾病综合征中尿蛋白及血浆白蛋白的影响

目的分析常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征中的治疗过程中,对患者尿蛋白及血浆白蛋白的影响。方法 80例原发性肾病综合征患者依病理类型分为2组,A组应用糖皮质激素,B组为应用糖皮质激素加细胞毒类药物。再将2组各随机分为2组,即应用甲泼尼龙组（治疗组）、口服泼尼松组（对照组）,进行疗效分析。结果常规剂量甲泼尼龙、泼尼松序贯疗法较常规泼尼松疗法,在尿蛋白的减少机血浆白蛋白的恢复方面均优于对照组,差异有统计学意义（P〈0.05）。结论常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征治疗中较常规泼尼松应用能较快的减少尿蛋白及提高血浆白蛋白的水平。

Analysis of urine protein and plasma-albumin levelin primary nephrotic syndromewith sequential therapy by regular dose methylprednisolone and prednisone

Objective To analyze theefficacyof urine protein and plasma--albumin withregular dose methylprednisolone, prednisone of sequential therapy in primary nephrotic syndrome. Methods 80 patients with primary nephrotic syndrome were divided into two groups according to pathological type, glucocorticoids group （A）, and another group （B）with glucocorticoid and cytotoxic drugs. Then each groupwas randomly divided into two groups, namely, the application of methylprednisolone group （treatment group） and oral prednisone group （control group）, and made an curative effect analysis. Results The effect o1 the 24 hour urinary protein excretion, plasma albumin, cholesterol in treatment groupwas superior to those in the control group, There was no significantstatistical difference （P〈 0.05）. Conclusion The treatment of the regular dose of methylprednisolone, prednisone sequential therapy can more quickly relieve the urine protein and increase plasma-albuminthan regular prednisone application in primary nephrotic syndrome.