MTHFR基因A1298C位点多态性与头颈癌易感性的Meta分析

目的:运用Meta分析研究MTHFR基因A1298C位点多态性与头颈癌易感性的关系。方法:检索CBM,CNKI和PubMed数据库中有关MTHFR基因A1298C位点多态性与头颈癌易感性关联研究的文献,对符合纳入标准的文献进行资料提取后,应用STATA 11.0软件进行Meta分析及检测发表偏倚。结果:纳入10个病例-对照研究,共计3 534例头颈癌患者和6 418例正常人群对照。Meta分析结果显示,总人群中,MTHFR基因A1298C多态性与头颈癌风险之间没有显著关联[CC vs AA:OR=1.07,95%CI=0.70~1.65,P=0.75,P heterogeneity<0.001;AC vs AA:OR=1.06,95%CI=0.88~1.27,P=0.57,P heterogeneity<0.001;(CC+AC)vs AA:OR=1.06,95%CI=0.86~1.30,P=0.57,P heterogeneity<0.001;CC vs(AA+AC):OR=1.02,95%CI=0.69~1.52,P=0.91,P heterogeneity<0.001)]。在针对种族和对照人群来源设计的亚组分析中,仍未发现MTHFR基因A1298C多态性和头颈癌的发生风险具有相关性。结论:MTHFR基因A1298C位点多态性可能与头颈癌的发生无关。

Association Between MTHFR A1298C Polymorphism and Risk of Head and Neck Cancer: a Meta-analysis

Objective To investigate the association between MTHFR A1298C polymorphism and the risk of head and neck cancer by using meta-analysis approach.Methods The relevant literatures were searched from the database CBM,CNKI,Pubmed,and the data of genotype distributions and other information were extracted.The STATA 11.0 software was used to perform a meta-analysis and to test publish bias.Results Ten published case-control studies including 3 534 patients with head and neck cancer,6 418 controls were selected.The results of meta-analysis showed that MTHFR A1298C polymorphism had no significant association with the risk of head and neck cancer in the general population(CC vs AA: OR = 1.07,95% CI = 0.70 ~ 1.65,P = 0.75,P heterogeneity < 0.001;AC vs AA: OR = 1.06,95% CI = 0.88 ~ 1.27,P = 0.57,P heterogeneity < 0.001;CC + AC vs AA: OR = 1.06,95% CI = 0.86 ~ 1.30,P = 0.57,P heterogeneity < 0.001;CC vs AA + AC: OR = 1.02,95% CI = 0.69 ~ 1.52,P = 0.91,P heterogeneity < 0.001).In the subgroups analysis based on ethnicity and study design,the results still showed no significant association between them.Conclusion This meta-analysis demonstrated that MTHFR A1298C polymorphism may be not a risk factor in development of head and neck cancer.