常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征中的疗效分析

目的分析常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征中的疗效。方法 80例原发性肾病综合征患者依病理类型分为2组,A组应用糖皮质激素,B组为应用糖皮质激素加细胞毒类药物。再将上2组各随机分为2组,即甲泼尼龙组（治疗组）、口服泼尼松组（对照组）,进行疗效分析。结果常规剂量甲泼尼龙、泼尼松序贯疗法较常规泼尼松疗法在病情缓解率方面2组差异无统计学意义（P〉0.05）,但在24h尿蛋白定量、血浆白蛋白、胆固醇、水肿消退时间、尿蛋白转阴时间等方面均优于对照组,差异有统计学意义（P〈0.05）。结论常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征治疗中较常规泼尼松应用能较快地缓解患者的症状。

Analysis of therapeutic effect of sequential therapy in primary nephrotic syndrome with regular dose methylprednisolone and prednisone

Objective To analyze the efficacy of regular dose methylprednisolone, prednisone of sequential therapy in primary nephrotic syndrome. Methods 80 patients with primary nephrotic syndrome were divided into two groups according to pathological type, glucocorticoids group （A）, and another group （B）with glucocorticoid and cytotoxic drugs. Then each group was randomly divided into two groups, namely, the application of methylprednisolone group （treatment group） and oral prednisone group （control group）, and made a curative effect analysis. Results There was no statistical difference in the remission rate of the two groups between regular dose methylprednisolone, prednisone sequential therapy and regular prednisone therapy （P 〉 0.05）, but the effect of the 24--hour urinary protein excretion, serum albumin, cholesterol, edema and urinary protein clearance time in treatment group was superior to those in the control group, There was no significant statistical difference （P 〈0.05）. Conclusion The treatment of the regular dose of methylprednisolone, prednisone sequential therapy can more quickly relieve the patienfs symptom than regular prednisone application in primary nephrotic syndrome.