处方工艺对聚乙烯醇/魔芋胶复合水凝胶体外释药的影响

目的制备聚乙烯醇/魔芋胶复合凝胶,考察处方工艺因素对其体外释药的影响。方法以盐酸小檗碱为模型药物,采用冷冻-解冻法制备聚乙烯醇/魔芋胶复合凝胶。通过体外药物释放研究,考察凝胶材料用量、聚乙烯醇/魔芋胶比例、药物量、反复冷冻-解冻次数等因素对复合凝胶释药特性的影响。结果随着凝胶材料用量、载药量和冷冻-解冻次数增加,复合凝胶的释药速度减慢;聚乙烯醇/魔芋胶比例为2∶1时,药物释放最慢。结论聚乙烯醇/魔芋胶复合凝胶对盐酸小檗碱具有缓释效果,可通过处方工艺因素调节其释药特性。

Influences of formulation and preparation on in vitro drug released form Polyvinyl alcohol/Konjac glucomannan complex hydrogel

Objective To prepare polyvinyl alcohol （PVA）/konjac glucomannan （KGM） complex hydrogel, and investigate the influence of formulation and preparation factors on drug released. Methods The PVA/KGM complex hydrogel containing berberine hydrochloride as a model drug were prepared by freezing and thawing method of physical crosslinking of the PVA and KGM solution. The effects of the amount of matrix materials and drug, PVA/KGM ratio, and freezing and thawing cycle times on drug release characteristics were investigated. Results Berberine hydrochloride could be released slowly from the PVA/KGM complex hydrogel. With an increased in the amount of matrix materials and drug, freezing and thawing cycle times, the drug release rate was decreased. When the ratio of PVA/KGM was 2 ： 1, the drug release rate was the slowest.Conclusion The PVA/ KGM complex hydrogel can used as a sustained-release preparation for berberine hydrochloride, drug release characteristics can be controlled by adjusting the formulation and preparation.