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| 枸杞多糖对糖尿病小鼠模型免疫功能的影响 | |
| 引用本文： | 王玲,李维波,邓学端,张才军,谢蒲伶,蒋绿芝,赵翀. 枸杞多糖对糖尿病小鼠模型免疫功能的影响[J]. 现代免疫学, 2000, 20(3): 159-162 |
| 作者姓名： | 王玲 李维波 邓学端 张才军 谢蒲伶 蒋绿芝 赵翀 |
| 作者单位： | 1. 昆明医学院微生物学与免疫学教研室,昆明,650031 2. 昆明医学院物理学教研室 3. 昆明医学院第二附属医院内分泌科 4. 北京中国医学科学院动物所生殖生物学实验室 |
| 基金项目： | 云南省教委应用基金资助项目(9612117) |
| 摘 要： | 利用静脉注射四氧嘧啶 ( 10 0mg/kg)诱导制备糖尿病小鼠模型 ,观察LBP D对四氧嘧啶致糖尿病小鼠免疫功能的影响。研究表明 ,小鼠在注射四氧嘧啶后 72h ,灌胃 (ig )给予LBP D ,连续 10d ,糖尿病小鼠NS对照组免疫功能明显降低 ,而LBP D组显示LBP D具有明显促进小鼠淋巴细胞增殖、调节T淋巴细胞亚群及提高IL 1和IL 2水平的功能 ,使四氧嘧啶糖尿病小鼠免疫功能恢复接近正常。研究结果显示 ,LBP D对糖尿病模型小鼠有免疫调节治疗效应 |
| 关 键 词： | LBP-D 四氧嘧啶 糖尿病 淋巴细胞增殖 T淋巴细胞亚群 IL-1 IL-2 |
| 文章编号： | 1001-2478(2000)03-0159-04 |
| 修稿时间： | 1999-07-19 |
The Effects of LBP-D on Immune Functions in Alloxan-Induced Diabetes Mice |
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| Wang Ling,Li Weibo,Deng Xueduan,Zhang Caijun,Xie Puling,Jiang Luzhi,Zhao Chong. The Effects of LBP-D on Immune Functions in Alloxan-Induced Diabetes Mice[J]. Current Immunology, 2000, 20(3): 159-162 | |
| Authors: | Wang Ling Li Weibo Deng Xueduan Zhang Caijun Xie Puling Jiang Luzhi Zhao Chong |
| Affiliation: | Wang Ling,Li Weibo,Deng Xueduan,Zhang Caijun,Xie Pulin,Jiang Luzhi;(Department of Microbiology and Immunology, Kunming Medical College, Kuaming 650031) |
| Abstract: | An experiment diabetes mouse model was induced by intravenous injections of alloxan monohydrate (100mg/kg),and LBPD was administrated 72 hours after injections of alloxan for 10 successive days It was found that LBPD had a remarkablly enhancing effects on the immune functions including the enhancement of lymphocyte proliferation,upregulation in the numbers of T lymphocyte subsets,elevations of the IL1 and IL2 levels,and recovery of the immunocompromised functions of the alloxan-induced diabetes mice near to normal These experimental results implicate that LBPD appears to have a immunoregulatory effect on the alloxaninduced diabetes mice |
| Keywords: | LBP-D alloxan monohydrate diabetes lymphocytes proliferation T lymphocytes subpopulations IL-1 IL-2 |
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