首发抑郁症患者治疗前后悲伤体验的fMRI研究

目的:探讨首发抑郁症患者基于体素的全脑形态改变特点.方法:采用3.0T磁共振机,研究32例抑郁症患者及32例性别、年龄相匹配的正常志愿者.运用SPM2分析软件,采用基于体素的形态学方法,进行全脑比较分析.结果:抑郁症患者右侧海马、右侧杏仁核及右侧枕中回体积较正常对照组缩小(P<0.05,FDR-correct-ed).结论:首发抑郁症患者右侧海马、右侧杏仁核及右侧枕中回体积有明显缩小倾向.

Responses with Sad Emotional Processing in First-onset Major Depressive Disorder by Antidepressant Treatment Investigated with Functional MRI

Purpose: To detect changes of response toward sad facial expressions in first-onset major depressive disorder(MDD) by antidepressant treatment investigated with functional magnetic resonance imaging (fMRI) . Methods: Thirteen patients with first onset MDD and 14 normal age-matched volunteers underwent fMRI, and patients underwent scanning twice during an 8-week period. Blood oxy-genation level dependent (BOLD) images were processed using SPM2 to compare of function in whole brain between the two groups during exposure to neutral, positive and negative pictures. Results: Increased activation of anterior cingulate cortex (ACC) during exposure to sad pictures were found in patients compared with control groups(P< 0.001, uncorrected) . Symptomatic improvement after antidepressant was associated with reversion of ACC (P<0.001, uncorrected). Conclusion: Changes in response associated with symptomatic improvement indicate that fMRI may be a useful surrogate marker of antidepressant treatment response.