细胞周期调控因子P27kip1和周期蛋白E在胰腺癌发生发展中的作用

Theabnormalityofmammaliancellcycleregulationisanim－portantcauseofcellover－proliferationandoncogenesis犤１犦．Orderlyprogressionofthecellcycleiscontrolledbyafamilyofcyclinsandcyclin－dependentkinase（CDKs）whicharerestrictivelycounterbal－ancedbyCDKinhibitors（CDKIs）犤２犦．TwodistinctfamiliesofCDKIs，theINK４andCIP／KIPfamilieswhichregulatethetheactivityofthecyclin－CDKcomplexes，havebeendescribed．TheCIP／KIPfamily，includingp２１，p２７andp５７proteins，harborshomologousCDKb…

Effect of regulatory factor of cell cycle p27kip1 and cyclinE proteins on the genesis and progression of human pancreatic cancer

Objective To investigate effect of p27 kip1 and cyclinE proteins on the genesis a nd progression of human pancreatic c ancer.Methods The expression of p27 kip1 and cyclinE in tumor tissue and adjacent tissue of 32patients with pancre atic cancer were detected by SP immunohistochemical technique.Results p27 kip1 protein positive-expression rate i n tumor tissue of pancreatic cancer was 56%,which was lower than that in adjacent pancreatic tis sue(P <0.05),p27 kip1 protein positive-expression corre lated significantly with tumor cell differentiation and lymphy node metastasis(P <0.05);cyclinE positive-expression rate was 69%,which was higher than that in adjacen t pancreatic tissue(P <0.05),cyclinE positive-expression also c orrelated significantly with tumor cell differentiation and lymphy nod e metastasis(P <0.05).Con-clusions p27 kip1 and cyclinE proteins may play an important role in genesis and progressio n of pancreatic cancer.