| 眼用制剂中添加清凉剂的思考 |
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| 引用本文： | 胡士高,俞佳,宁黎丽,吕东.眼用制剂中添加清凉剂的思考[J].中国现代应用药学,2010,27(1):38-39. |
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| 作者姓名： | 胡士高 俞佳 宁黎丽 吕东 |
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| 作者单位： | 1.安徽省药品审评认证中心，合肥 230022；2.浙江省人民医院，杭州 310014；3.国家食品药品监督管理局药品审评中心，北京 100038 |
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| 摘 要： | 目前在眼用制剂的申报资料中,有较多研制单位采用薄荷脑、冰片、樟脑等作为清凉剂,而文献显示此类物质除具有一定活性外,还具有促进药物透皮吸收的作用。眼用制剂作为直接用于眼部发挥治疗作用的药物制剂,在辅料选择方面应慎重。
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| 关 键 词： | 眼用制剂 清凉剂 薄荷脑 冰片 樟脑 |
Study on Colling-agent of Ophthalmic Preparation |
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| Institution: | HU Shigao,YU Jia,NING Lili,Lü Dong(1.Anhui Center for Drug Evaluation ＆ Certification,Hefei 230022,China;2.Zhejiang Provincial People＇ s Hospital,Hangzhou 310014,China;3.Center for Drug Evaluation,State Food and Drug Administration,Beijing 100038,China) |
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| Abstract: | Mentholum, borneolum syntheticum and camphor are normally used as cooling agents by developing companies according to existing application dossier of ophthalmic preparation. However, besides some activities, these materials can enhance permeation and absorption of active ingredients according to literatures. Thus, it should be cautious when selection of excipients for ophthalmic preparation that is used for eyes directly. |
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| Keywords: | ophthalmic preparation colling-agent mentholum borneolum syntheticum camphor |
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