CA125、D-二聚体在卵巢癌中的应用价值

卵巢癌发病率在妇科恶性肿瘤中居第3位，而病死率却居首位。卵巢癌起病隐匿，早期缺乏典型临床表现，易发生腹腔内播散转移，70%的患者就诊时已属晚期。虽然目前卵巢癌可经肿瘤细胞减灭术辅以化疗得到有效治疗，但因其复发率较高，晚期患者5年存活率仅为30%左右。早期诊断、有效治疗、降低复发对卵巢癌的预后有重要影响。研究者致力于寻找指标，如CA125、D-二聚体，以应用于卵巢癌的早期诊断、疗效观察及预后评估。综述CA125、D-二聚体在卵巢癌中的应用价值。

The Value of CA125 and D-dimer with Ovarian Cancer

Ovarian cancer is the third common cause of cancer-related mortality among women, but it is the leading cause of death from gynecologic cancers. More than 70% of the women are diagnosed at late stage disease. The reason for this is that the tumor, which develops from the ovarians located in the peritoneal cavity, may grow quite large and metastasize before it is diagnosed because of lack of symptoms. Moreover, it has a high recurrence rate even with optimal cytoreductive surgery and effective chemotherapy. So the 5-year overall survival rate for women diagnosed with late stage disease is only about 30%. Early diagnosis, effective treatment and reduce the recurrence of ovarian cancer have important impacts on prognosis. Researchers dedicated to finding indicators, such as CA125, D-dimer, which can be used in early diagnosis of ovarian cancer, treatment response monitoring and prognosis. In this paper, CA125 and D-dimer in the value of ovarian cancer start review.