| 细胞因子在白癜风发病机制中的作用 |
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| 引用本文： | 周隽,傅雯雯. 细胞因子在白癜风发病机制中的作用[J]. 国际皮肤性病学杂志, 2009, 35(1). DOI: 10.3760/cma.j.issn.1673-4173.2009.01.020 |
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| 作者姓名： | 周隽 傅雯雯 |
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| 作者单位： | 复大学附属华山医院皮肤科,上海,20040 |
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| 摘 要： | 白癜风由于表皮黑素细胞的功能丧失而引起.细胞因子通过自分泌或旁分泌的方式影响黑素细胞的生物学特性.多种细胞因子及黑素细胞表面存在的细胞因子受体在黑素细胞的生长,分化、增殖、凋亡及其黑素产生及转运过程中起重要作用.促黑素细胞激素、粒细胞一巨噬细胞集落刺激因子、干细胞因子、碱性成纤维细胞生长因子等促进黑素细胞的生长、分化、增殖,肿瘤坏死因子-α、白介素等抑制黑素细胞生长.
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| 关 键 词： | 白癜风 黑素细胞 细胞因子类 |
Roles of cytokines in the pathogenesis of vitiligo |
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| ZHOU Jun,FU Wen-wen. Roles of cytokines in the pathogenesis of vitiligo[J]. International Journal of Dermatology and Venereology, 2009, 35(1). DOI: 10.3760/cma.j.issn.1673-4173.2009.01.020 |
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| Authors: | ZHOU Jun FU Wen-wen |
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| Abstract: | Vitiligo is associated with the function loss of epidermal melanocytes.Cytokines can affect the biological characters of melanocytes through autocrine or paracrine modes of action.Several kinds of cytokines and their receptors on melanocytes play important roles in the growth,differentiation,proliferation,apoptosis,production and transpon of melanin,of melanocytes.It has been demonstrated that the growth,differentiation and prolifemtion of melanocytes can be promoted by melanocyte-stimulating hormone,granulocyte-macrophage colony stimulating factor,stem cell factor,basic fibroblast growth factor,etc,whereas tumor necrosis factor α and interleukin have an inhibitory effect on the growth of melanocytes. |
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| Keywords: | Vitiligo Melanocytes Cytokines |
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