耐多药肺结核患者生命质量的变化和影响因素

目的 探讨耐多药肺结核(MDR-TB)患者生命质量的变化及影响因素.方法 用SF-36量表对80例正常人和80例MDR-TB患者进行治疗前后生命质量总评分及各维度得分评价疗效.结果 治疗前MDR-TB患者的生命质量(Qol)总分及8个维度得分均低于正常对照组(均P＜0.01);治疗后的生命质量总分及8个维度的得分明显高于治疗前(均P＜0.01);治疗1年后的总分及PF、PR、GH、VT、SF、ER、MH 7个维度较对照组低,并差异有统计学意义(P＜0.05);影响MDR-TB患者生命质量的主要因素是:文化程度、耐药数目、WBC降低.结论 MDR-TB患者生命质量与文化程度、耐药数目、WBC降低有关.

The changes of quality of life and influence factors in patients with multi-drugresistant pulmonary tuberculosis

Objective To discuss the changes of quality of life and influence factors in patients with multidrugresistant pulmonary tuber-culosis. Methods Using the SF-36 scale of 80 normal subjects and 80 cases of MDRTB patients before and after treatment and quality of life score total score evaluated dimensions. Results Between the patients with MDR-TB and the control in the total Qol scores and eight dimensionality, there were significant differences(P＜0.01), total Qol scores and eight dimensionality in 3 months or 1 year after treatment were higher than before therapy,there were significant differences(P＜0.01 ). Between 1 year after therapy in the total Qol scores and PF, PR, GH, VT, SF, ER, MH, dimensionality were lower than control groups, there were significant differences(P＜0.05 ). The main factors affecting the Qol of patients with MDR-TB were cultural level, kinds of drug resistant and reduction of counts of white blood cell. Conclusion The correlation between quality of life and education, the number of drug resistance, reduction of white blood cell in patients with multi-drugresistant pulmonary tuberculosis.