| 蒙古沙鼠感染幽门螺旋杆菌后胃黏膜细胞因子水平的改变 |
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| 引用本文： | 王晶桐,刘玉兰. 蒙古沙鼠感染幽门螺旋杆菌后胃黏膜细胞因子水平的改变[J]. 胃肠病学和肝病学杂志, 2008, 17(1): 50-51 |
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| 作者姓名： | 王晶桐 刘玉兰 |
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| 作者单位： | 北京大学人民医院消化科,北京,100044 |
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| 摘 要： | 目的探讨幽门螺旋杆菌感染后胃黏膜重要细胞因子的改变，为免疫治疗提供理论依据。方法制作幽门螺旋杆菌感染蒙古沙鼠的动物模型，感染6周后处死动物，证实幽门螺旋杆菌定植成功，以RT—PCR方法检测胃黏膜IFN-γ、IL-12、IL-18的水平。结果幽门螺旋杆菌感染组IFN／G3PDH、IL-12／G3PDH分别为1．19±0．86、1．85±0．96，高于对照组；感染组和对照组之间IL-18／G3PDH无显著性差异。结论 IFN-1、IL-12水平的改变可能参与了幽门螺旋杆菌的致病过程。
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| 关 键 词： | 幽门螺旋杆菌 细胞因子 |
| 文章编号： | 1006-5709（2008）01-0050-02 |
| 收稿时间： | 2007-03-30 |
| 修稿时间： | 2007-03-30 |
Gastric mucosal cytokine changes post-Helicobacter pylori infection in mongolian gerbils |
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| WANG Jingtong,LIU Yulan. Gastric mucosal cytokine changes post-Helicobacter pylori infection in mongolian gerbils[J]. Chinese Journal of Gastroenterology and Hepatology, 2008, 17(1): 50-51 |
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| Authors: | WANG Jingtong LIU Yulan |
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| Affiliation: | WANG Jingtong, LIU Yulan( Department of Gastroenterology, People＇ s Hospital, Beijing University, Beijing 100044,China) |
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| Abstract: | Objective To investigate gastric mucosal cytokine responses in Mongolian gerbils infected with H. pylori. Methods Mongolian gerbils were infected with H. pylori by gavage. At 6 weeks post-infection, animal models were ex-ecuted. IFN-γ, IL-12, IL-18 were tested by RT-PCR. Results The ratios of IFN/G3PDH, IL-12/G3PDH of gerbils infected with helicobacter pylori were 1.19 ± 0.86, 1.85 ±0.96 respectively, higher than those of control group. As about the ratio of IL-18/G3PDH, there was no difference of the infected group and controlled group. Conclusion IFN- γ,IL-12 may involve the pathogenesis of H. pylori infection. |
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| Keywords: | Helicobacter pylori Cytokine |
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