| 雷公藤多甙的抗炎和免疫抑制作用 |
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| 引用本文： | 力弘,贾永锋,李端. 雷公藤多甙的抗炎和免疫抑制作用[J]. 复旦学报(医学版), 2000, 27(6): 502-505 |
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| 作者姓名： | 力弘 贾永锋 李端 |
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| 作者单位： | 上海医科大学药学院药理学教研室上海 200032 |
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| 摘 要： | 目的探讨雷公藤多甙(T
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| 关 键 词： | 雷公藤多甙； 抗炎剂； 抗变态反应； 溶血素 |
| 修稿时间： | 1999-12-30 |
Effects of Polyglycosides of Tripterygium Wilfordii Hook on Inflammation and Immune Suppression |
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| LI Hong,JIA Yong-feng,LI Duan. Effects of Polyglycosides of Tripterygium Wilfordii Hook on Inflammation and Immune Suppression[J]. Fudan University Journal of Medical Sciences, 2000, 27(6): 502-505 |
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| Authors: | LI Hong JIA Yong-feng LI Duan |
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| Abstract: | Purpose To study the anti-inflammatory,anti-allergy and immunosuppressive effect of polyglycosides of tripterygium wilfordii Hook (TⅡ). Methods Animal model of acute and subacute inflammation,adjuvant arthritis,type Ⅳ and Ⅲ allergic reaction were used.Serum haemolysin level,lymphocyte proliferation and T-cell subsets in spleen were tested. Results TⅡ 60,120 mg/kg and pre(prednisone)10 mg/kg had marked inhibitory effect on carrageenine induced swelling,tampon induced granulation and on the prevention of adjuvant arthritis.The delayed type hypersensitivity reaction(type Ⅳ) and arthus reaction (type Ⅲ) was distinctly suppressed.It had a suppressive action on serum haemolysin and lymphocyte proliferation with and without concanavatin A which was dose dependent.In the T-cell subsets:TⅡ 60 mg/kg decreased TS and TⅡ 120 mg/kg inhibited both TS and TH,preacted mainly on TH and rendered the decreased ratio of TH/TS. Conclusions TⅡ has suppressive effect on inflammation,allergic reaction and immune function. |
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| Keywords: | polyglycosides of tripterygium wilfordii Hook anti inflammatory agent anti allery haemolysin lymphocyte proliferation T cell subsets |
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