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Obesity and Mental Illness: Implications for Cognitive Functioning |
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| Authors: | Roger S McIntyre Danielle S Cha Jeanette M Jerrell Joanna K Soczynska Hanna O Woldeyohannes Valerie Taylor Oksana Kaidanovich-Beilin Mohammad Alsuwaidan Ameena T Ahmed |
| Institution: | 1. Department of Psychiatry, University of Toronto, Toronto, ON, Canada 2. Department of Pharmacology, University of Toronto, Toronto, ON, Canada 3. Institute of Medical Science, University of Toronto, Toronto, ON, Canada 4. Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street, Toronto, M5T 2S8, ON, Canada 5. Department of Neuropsychiatry, University of South Carolina School of Medicine, Columbia, SC, USA 6. University of Toronto, Toronto, ON, Canada 7. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 983, Toronto, ON, M5G 1X5, Canada 8. The Permanente Medical Group, San Francisco, CA, 94115, USA 9. Kaiser Permanente Division of Research, San Francisco, CA, 94115, USA |
| Abstract: | A priority research and clinical agenda is to identify determinants of cognitive impairment in individuals with neuropsychiatric disorders (NPD). The bidirectional association between NPD and cognitive performance has been reported to be mediated and/or moderated by obesity in a subset of individuals. Obesity can be conceptualized as a neurotoxic phenotype among individuals with NPD as evidenced by alterations in the structure and function of neural circuits and disseminated networks, diminished cognitive performance, and adverse effects on illness trajectory. The neurotoxic effect of obesity provides a rationale for screening, treating, and preventing obesity in neuropsychiatric populations. Research endeavors that aim to refine mediators and moderators of this association as well as novel strategies to reverse the injurious process of obesity on cognition are warranted. |
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