超敏C反应蛋白和尿路感染信息在尿路感染诊断中的应用

目的探讨超敏C反应蛋白（hs-CRP）及尿路感染信息（UTI-Info）对尿路感染（UTI）的诊断价值。方法对380例疑似UTI患者的尿标本进行尿培养,用UF-1000i全自动尿液有形成分分析仪测定白细胞数（WBC）及细菌数（BACT）,得到UTI-Info;用AU2700全自动生化分析仪测定静脉血hs-CRP含量;以细菌定量培养结果为标准对照,评估hs-CRP、UTI-Info、hs-CRP＋UTI-Info诊断UTI的灵敏度、特异性、诊断符合率等。结果除污染标本外,余下360份标本中,细菌培养结果阳性有102份,阳性率为28.3%。以细菌培养为参考方法,hs-CRP诊断UTI的灵敏度、特异性、诊断符合率分别为85.3%、70.9%、75.0%;UTI-Info诊断UTI的灵敏度、特异性、诊断符合率分别为76.5%、84.5%、82.2%;hs-CRP＋UTI-Info诊断UTI的灵敏度、特异性、诊断符合率分别为70.6%、97.3%、89.7%。结论 hs-CRP联合UTI-Info能快速诊断UTI并能提高特异性及诊断的准确性。

Using the high sensitivity c-reactive protein and urinary tract infection information in the diagnosis of urinary tract infection

Objective To evaluate the application value of using the high sensitivity c-reactive protein （hs-CRP） and urinary tract infection information （UTI-Info） in diagnosis of urinary tract infection （UTI）. Methods 380 urine specimens from suspected UTI patients were cultured for bacterial identification. UF-1000i automated urine analyzer was used to detect white blood cell count （WBC） and bacterial count （BACT）. AU2700 automatic biochemistry analyzer was used to detect hs-CRP in venous blood. Bacterial cell count was used as standard for the evaluation of sensitivity, specificity and diagnostic accordance rate of hs-CRP, UTI-Info and hs-CRP＋UTI-Info. Results Except the contaminated samples, 102 out of 360 samples （28.3%） were positive for bacterial growth. The sensitivity, specificity and diagnostic accordance rate of hs-CRP in the diagnosis of UTI were 85.3%, 70.9% and 75.0%, respectively. The sensitivity, specificity and diagnostic accordance rate of UTI-Info in the diagnosis of UTI were 76.5%, 84.5% and 82.2%, respectively. The sensitivity, specificity and diagnostic accordance rate of hs-CRP＋UTI-Info in the diagnosis of UTI were 70.6%, 97.3% and 89.7%, respectively. Conclusion The combination of hs- CRP and UTI-Info can be used for the fast and specific diagnosis of UTI.