| 肺纤维化模型研究进展 |
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| 引用本文： | 刘干,李俊,高建,贾丽莎. 肺纤维化模型研究进展[J]. 安徽医药, 2010, 14(10): 1117-1120. DOI: 10.3969/j.issn.1009-6469.2010.10.001 |
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| 作者姓名： | 刘干 李俊 高建 贾丽莎 |
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| 作者单位： | 安徽医科大学药学院,安徽,合肥,230032;安徽医科大学药学院,安徽,合肥,230032;安徽医科大学第一附属医院药剂科,安徽,合肥,230022 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 肺纤维化（pulmonary fibrosis,PF）是一种严重的肺间质疾病,由于缺乏有效的药物治疗,其预后不良。这使得新的治疗药物的研究迫在眉睫,而建立良好的肺纤维化模型是进行药物研究的基础。本文通过整理和比较肺纤维化体内、体外多种模型的建立方法,以期为肺纤维化的药物研究提供良好的实验基础。
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| 关 键 词： | 肺纤维化 博莱霉素 体内模型 体外模型 |
Research progress on pulmonary fibrosis model |
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| LIU Gan,LI Jun,GAO Jian,JIA Li-sha. Research progress on pulmonary fibrosis model[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(10): 1117-1120. DOI: 10.3969/j.issn.1009-6469.2010.10.001 |
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| Authors: | LIU Gan LI Jun GAO Jian JIA Li-sha |
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| Affiliation: | LIU Gan1,LI Jun1,GAO Jian1,2,JIA Li-sha1(1.School of Pharmacy,Anhui Medical University,Hefei 230032,2.Dept of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Pulmonary fibrosis(PF) is a severe chornic interstitium disease in the lung.The prognosis of this disease is unfavourable ow-ing to the lack of effective drug therapies.So the new drugs researches of PF are eagerly requested.And making sucessful models of pul-monary fibrosis is the foundation of drug research.In this article,we expect to provide a satisfactory foundation for the drug researche of PF by sorting and comparing multiple methods of establing vitro models and vivo models of pulmonary fibrosis. |
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| Keywords: | pulmonary fibrosis bleomycin vitro model vivo model |
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