Inosiplex enhances the growth of Epstein-Barr nuclear antigen-positive B-cells from patients with rheumatoid arthritis and infectious mononucleosis |
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| Authors: | H Becker K Helmke |
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| Institution: | 1. School of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil;2. Center for Biological and Health Sciences, Regional University of Cariri, URCA, Crato, Brazil;3. Ceará Cancer Institute, ICC, Fortaleza, Ceará, Brazil;1. Department of Physics, JNN College of Engineering, Shivamogga 577 204, Karnataka, India;2. Department of PG Studies and Research in Physics, Government Science College, Chitradurga 577 501, Karnataka, India;3. Department of Electronic Engineering, Institute for Wearable Convergence Electronics, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Republic of Korea;4. Department of Electrical and Electronics Engineering Science, University of Johannesburg, Auckland Park Campus, Johannesburg 2006, South Africa |
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| Abstract: | The in vitro effects of inosiplex (INO) on proliferation of Epstein-Barr virus (EBV)-carrying B-cells were evaluated. As measured by 3H-thymidine uptake, INO significantly augmented the proliferation of long-term cultured Epstein-Barr nuclear antigen (EBNA)-positive B-cells which were obtained from patients with rheumatoid arthritis (RA) and infectious mononucleosis (IM). In co-culture experiments, INO and anti-immunoglobulin M antibodies coupled to sepharose (anti-mu) had additive effects on proliferation of EBNA-positive B-cells. We conclude that its direct effects on B-cell function should be considered when INO is used for the treatment of diseases characterized by B-cell hyperreactivity. |
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